Irritease is designed to specifically treat the condition known as Irritable Bowel Syndrome. A Liver-Spleen disharmony is the primary manifestation, which may be complicated by other disease patterns. The Liver and Spleen interact with each other on the ke or restraining cycle in five phase theory. In a pattern of disharmony the restraining Liver Qi may cause stagnation, oppression and ultimately vacuity where diarrhea and pain are the main manifestations. Due to the Spleen Qi vacuity, Dampness will be generated internally and its turbidity will drain downward. When this turbid Damp combines with depressed Liver Qi, pain, borborygmus and diarrhea result. A commonly seen pattern with a Liver-Spleen disharmony is Damp-Heat in the Stomach and intestines. The accumulation of turbid Damp in the Middle and Lower Burners will ostruct the transformative action of the Yang Qi and over time will transform into Damp-Heat, creating such symptoms as dark odorous stools, mouth and tongue sores, thirst, vaginitis, acne and general Damp-Heat conditions. Herbs such as Yin chen hao, huang bai and huang lian have been added to help address this problem. This prescription is the same as the one used in a double-blind placebo trial done specifically to test its effectiveness in treating Irritable Bowel Syndrome.

Yin chen hao - Capillaris herb
Bai zhu - White atractylodes rhizome
Dang shen - Codonopsis root
Wu wei zi - Schisandra fruit
Yi yi ren - Job's tears seed
Chai hu - Bupleurum root
Che qian zi - Plantain seed
Fu ling - Poria
Hou po - Magnolia bark
Huang bai - Phellodendron bark
Guang huo xiang - Patchouli herb
Pao jiang - Prepared ginger rhizome
Qin pi - Chinese ash bark
Zhi gan cao - Honey fried Chinese licorice root and rhizome
Bai shao - White peony root
Chen pi - Tangerine dried rind of mature fruit
Huang lian - Coptis rhizome
Fang feng - Siler root
Mu xiang - Saussurea root
Bai zhi - Fragrant angelica root